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A Significant positive correlation has also been described between levels of reactive oxygen species (ROS) and percentage of spermatozoa with several types of abnormalities such as, abnormal heads, acrosome abnormalities, mid piece anomalies, cytoplasmic droplets and tail defects [25]

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Subsequently, the proliferation of endothelial cells increases, angiogenesis in breast cancer is improved, and hypoxia is further exacerbated

Most notably, it was shown that ROS are not only incidental side-products of metabolism but also generated by systems that have evolved to do so in a programmed manner (Doke 1985